Management of chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
Management of chronic lymphocytic leukemia.
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) is usually diagnosed in asymptomatic patients with early-stage disease. The standard management approach is careful observation, irrespective of risk factors unless patients meet the International Workshop on CLL (IWCLL) criteria for "active disease," which requires treatment. The initial standard therapy for most patients combines a...
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In the last decade, the management of chronic lymphocytic leukemia has undergone profound changes that have been driven by an improved understanding of the biology of the disease and the approval of several new drugs. Moreover, many novel drugs are currently under evaluation for rapid approval or have been approved by regulatory agencies, further broadening the available therapeutic armamentari...
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CLL is characterized by the gradual accumulation of malignant lymphocytes in the bone marrow, blood, lymph nodes, liver, and spleen. Thus, the major clinical features are the sequelae of bone marrow failure and the compressive syndromes that result from gross enlargement of lymphoid organs. In addition, CLL is associated with humoral and cell-mediated immunodeficiencies as well Chronic Lymphocy...
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Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2014
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2013.096107